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A geometrical perspective on cell fate specification

Speaker: Archishman Raju (NCBS, Bangalore)
Speaker: Archishman Raju (NCBS, Bangalore)
When Jan 16, 2024
from 04:00 PM to 05:00 PM
Where Lecture Hall- LH 111 (Hybrid)
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Abstract: Cell fate decisions emerge as a consequence of a complex set of gene regulatory networks. Models of these networks are known to have more parameters than data can determine. Recent work, inspired by ideas that originated in early experimental embryology, has instead tried to take a geometrical perspective and describe cell fate decisions as a landscape. We will describe recent results on the appropriate mathematical framework for constructing these landscapes. This allows the construction of minimally parameterized models consistent with cell behavior. We will give examples from the early mouse embryo as well as how landscapes can be constructed for Turing patterns.

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